منابع مشابه
Cross-reactive Idiotype of Human Anti-Thyroglobulin Autoantibodies
Pooled normal polyspecific IgG for therapeutic use (IVIg) contain anti-idiotypes against idiotypic determinants expressed by autoantibodies from patients with a variety of autoimmune diseases. In the present study, antiidiotypes in IVIg are shown to recognize a cross-reactive idiotype on human anti-thyroglobulin (TG) autoantibodies, that was defined by heterologous antiidiotypic antibodies, ter...
متن کاملRelationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA.
INTRODUCTION Studies suggest that respiratory exposures including smoking, proximity to traffic and air pollution might be associated with development of rheumatoid arthritis (RA). RA-related autoantibodies are predictive of the development of RA. OBJECTIVE We evaluated the relationship between RA-related autoantibodies and exposure to particulate matter (PM), a measure of air pollution of in...
متن کاملDelineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide
Antibody against a cross-reactive idiotype (CRI) on human IgM-rheumatoid factor (RF) antibodies was induced by immunization of rabbits with a synthetic peptide ( PSL2 ) corresponding to the second complementarity-determining region (CDR), and adjacent amino acid residues of the kappa light chain of the IgM-RF Sie . The anti-peptide antibody bound efficiently to IgM-RF proteins known to share a ...
متن کاملHuman transaldolase and cross-reactive viral epitopes identified by autoantibodies of multiple sclerosis patients.
Multiple sclerosis is mediated by an autoimmune process causing selective destruction of oligodendrocytes. Transaldolase, which is expressed in the brain selectively in oligodendrocytes, is a target of high affinity autoantibodies in serum and cerebrospinal fluid of multiple sclerosis patients. A three-dimensional model of human transaldolase was developed based on the crystal structure of the ...
متن کاملRA autoantibodies as predictors of rheumatoid arthritis in non-cystic fibrosis bronchiectasis patients.
Two studies have investigated RF in bronchiectasis [5, 6] with no studies to date investigating anti-CCP. In our BRAC RA (Bronchiectasis, Asthma, Control, Rheumatoid Arthritis) study, a prospective, multicentre, case–control, observational study was conducted to determine the relationship between bronchiectasis and RF and anti-CCP. Recruitment was completed over 12 months using identical method...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2020
ISSN: 1759-4790,1759-4804
DOI: 10.1038/s41584-020-0402-8